Aconitine mediates connexin43 and PKC phosphorylation status in cultured ventricular myocytes of neonatal rats
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چکیده
منابع مشابه
Unusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat
TRPV4 protein forms a Ca2+-permeable channel that is sensitive to osmotic and mechanical stimuli and responds to warm temperatures, and expresses widely in various kinds of tissues. As for cardiac myocytes, TRPV4 has been detected only at the mRNA level and there were few reports about subcellular localization of the protein. The purpose of the present study was to investigate the expression pr...
متن کاملImpulse conduction and gap junctional remodelling by endothelin-1 in cultured neonatal rat ventricular myocytes
Endothelin-1 (ET-1) is an important contributor to ventricular hypertrophy and failure, which are associated with arrhythmogenesis and sudden death. To elucidate the mechanism(s) underlying the arrhythmogenic effects of ET-1 we tested the hypothesis that long-term (24 hrs) exposure to ET-1 impairs impulse conduction in cultures of neonatal rat ventricular myocytes (NRVM). NRVM were seeded on mi...
متن کاملRole of protein kinase C-e in hypertrophy of cultured neonatal rat ventricular myocytes
Strait, James B., III, Jody L. Martin, Allison Bayer, Ruben Mestril, Diane M. Eble, and Allen M. Samarel. Role of protein kinase C-e in hypertrophy of cultured neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 280: H756–H766, 2001.—Using adenovirus (Adv)-mediated overexpression of constitutively active (ca) and dominantnegative (dn) mutants, we examined whether protein kinase C...
متن کاملEffects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes.
OBJECTIVES To elucidate signal transduction pathways regulating expression of myocardial gap junction channel proteins (connexins) and to determine whether mediators of cardiac hypertrophy might promote remodeling of gap junctions, we characterized the effects of angiotensin II on expression of the major cardiac gap junction protein connexin43 (Cx43) in cultured neonatal rat ventricular myocyte...
متن کاملGap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes.
OBJECTIVES Altered gap junctional coupling of ventricular myocytes plays an important role in arrhythmogenesis in ischemic heart disease. Since hypoxia is a major component of ischemia, we tested the hypothesis that hypoxia causes gap junctional remodeling accompanied by conduction disturbances. METHODS Cultured neonatal rat ventricular myocytes were exposed to hypoxia (1% O(2)) for 15 min to...
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ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2011
ISSN: 1996-0816
DOI: 10.5897/ajpp10.392